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Asian Journal of Pharmaceutical Research
Year : 2015, Volume : 5, Issue : 1
First page : ( 31) Last page : ( 36)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2015.00005.2

Simultaneous Determination of Propranolol Hydrochloride and Hydrochlorothiazide in Tablets Formulation using Spectrophotometric Technique (First Derivative Method)

Savaj Bhadresh V.1,*, Patidar Ashutosh Kumar2, Raj Hashumati A.1

1Department of Quality Assurance, Shree Dhanvantry Pharmacy College, Kim, Surat

2Department of Pharmaceutical Chemistry, Shree Dhanvantry Pharmacy College, Kim, Surat

*Corresponding Author E-mail: bhadresh.savaj@gmail.com

Online published on 2 May, 2015.

Abstract

A new spectrophotometric method was developed for simultaneous determination of compounds with interfering spectra in binary mixtures without previous separation, showing significant advantages over the conventional methods regarding minimal data manipulation and applicability. The proposed method was applied for the determination of Propranolol hydrochloride and Hydrochlorothiazide in Tablets formulation, for determination of sampling wavelength, 10 μg/ml of each of PRO and HCT were scanned in 200–400 nm range and sampling wavelengths were 293 nm for PRO and 334 nm for HCT are selected for development and validation of first derivative method. For this method linearity observed in the range of 10–50 μg/ml for PRP and 5–25 μg/ml for HCT and in their pharmaceutical formulation with mean percentage recoveries 100.66 ± 0.032 and 100.020 ± 0.031, respectively. The method was validated according to ICH guidelines and can be applied for routine quality control testing.

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Keywords

Spectroscopic method, first derivative method, propranolol hydrochloride, hydrochlorothiazide.

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