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Asian Journal of Pharmaceutical Research
Year : 2020, Volume : 10, Issue : 3
First page : ( 149) Last page : ( 159)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2020.00027.1

Formulation and evaluation of berberine hcl as niosomal drug delivery system

Awate Pooja S.*, Pimple Tejashree P., Pananchery Jeeja F., Jain Ashish S.

Shri D. D. Vispute College of Pharmacy and Research Center, Panvel-410206, Dist - Raigad (M.S), India

*Corresponding Author E-mail: poojjaawate95@gmail.com

Online published on 16 September, 2020.

Abstract

Non-ionic surfactant based vesicles known as niosomes. Vesicular system are lamellar structure, which delivery both the drug (hydrophobic and hydrophilic), encapsulated into interior hydrophilic compartment and outer lipid layer respectively. Berberine HCl noisome gel formulation show anti-microbial activity. Berberine HCl is an isoquinoline alkaloid which shows anti- microbial activity on various bacteria and fungi. The formulation of Berberine HCl noisome was prepared by using thin-film hydration technique by using different concentration of non-ionic surfactant span60 and cholesterol with optimized various process variables. The optimized gel formulation of niosomes was characterized for entrapment efficiency, particles size, transmission electron microscopy, zeta potential and in-vitro drug release study. The stability study was performed at various temperature.

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Keywords

Berberine HCl, Niosome, Lamellar, Encapsulated.

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