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Asian Journal of Pharmaceutical Research
Year : 2020, Volume : 10, Issue : 2
First page : ( 73) Last page : ( 80)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2020.00014.3

Evaluation of Disintegration Efficacy of Starch Citrate in Tablet Formulations

Debnath Subhashis1,*, Gayathri V. G.2, Swetha D.2, Babu M. Niranjan2

1Royal School of Pharmacy, The Assam Royal Global University, Guwahati, Assam, India

2Department of Pharmaceutics, Seven Hills College of Pharmacy, Venkatramapuram, Tirupati, Andhra Pradesh, India

*Corresponding Author E-mail: sdebnath@rgu.ac

Online published on 3 June, 2020.

Abstract

Starch citrate was prepared by reacting potato starch with citric acid at elevated temperatures which exhibited good flow property and it had good swelling property without pasting when heated in water considered to be a promising excipient. Tablets of paracetamol were prepared by wet granulation method employing starch citrate at different % (4–10) strength as disintegrant in the tablets. For comparision tablets were also prepared by using sodium starch glycolate, starch and starch citrate (50 50) at same varying concentrations (4%, 6%, 8%, 10%). Results of FTIR were revealed that there were no interaction between drug, starch citrate and other excipients. Pre-compression parameters like angle of repose, compressibility index (%), bulk and tapped densities, hausner's ratio were carried out to determine the flow property. All tablets were of good quality with regard to post compression parameters like weight variation, hardness, friability, and drug content. The f7 and f8 (8% and 10% starch citrate) formulations were disintegrated with in 40 and 34 seconds where as f15 and f16 (8% and 10% scg) formulation were disintegrated with in 53 and 39 seconds respectively. The starch citrate exhibit similar disintegration properties like sodium starch glycolate tablets at 8 and 10% concentrations. Hence starch citrate can be considered as a promising super disintegrant agent in tablet formulations and it can be concluded as a economical and better choice for commercial use.

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Keywords

Disintegrant, starch citrate, hausner's ratio, formulations.

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