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Asian Journal of Pharmaceutical Research
Year : 2020, Volume : 10, Issue : 2
First page : ( 62) Last page : ( 66)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2020.00012.X

Comparative study of In-Vivo effects of Glipizide and Metformin HCl on plasma concentration of Aminophylline in healthy rabbits

Palaksha MN1, Mani T Tamizh1, Manjunatha E2,*, Kumar G P Senthil1

1Bharathi College of Pharmacy, Bharathinagara, Mandya-571422

2Siddaganga College of Pharmacy, Tumkur-572102

*Corresponding Author E-mail: manjupharma@gmail.com

Online published on 3 June, 2020.

Abstract

A drug interaction is the modification of the effects of one drug in the presence of other drug. The interaction can modify the drugs by forming chemical complex, nullify the action, increase the effect, decrease the effect, induce or inhibit the hepatic metabolism and elimination rate of the one drug in presence of other drug. The in-vivo effects of Glipizide and Metformin Hcl on plasma concentration of Aminophylline have been studied in rabbits. In this study, the plasma concentration of Aminophylline was determined by UV spectroscopic method using calibration curve, after oral single administration of Aminophylline alone and with Glipizide and Metformin HCL in rabbits was determined. The results have shown that Aminophylline can enhance both Glipizide and Metformin HCl plasma concentration in rabbits. The data obtained would help us to suggest that Glipizide as well as Metformin HCl may result into compatible combination therapies with Aminophylline an antiasthmatic drug is useful in the treatment of diabetic patients.

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Keywords

Drug-Interaction, Metformin, Aminophylline, Glipizide, UV-Spectrophotometer.

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