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Asian Journal of Pharmaceutical Analysis
Year : 2019, Volume : 9, Issue : 3
First page : ( 167) Last page : ( 176)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2019.00030.9

Analytical Techniques for Estimation of Rosiglitazone

Rajput Prashant, Firke Sandip*

Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India

*Corresponding Author E-mail: sandipfirke@rediffmail.com

Online published on 31 December, 2019.

Abstract

Rosiglitazone is a thiazolidinedione class of antidiabetic agent utilized in the treatment of patients having Type 2 diabetes. It works as an insulin sensitizer, by binding to the peroxisome proliferator-activated receptor-γ (PPARγ) in fat cells and making the cells more responsive to insulin. The present review highlights the published analytical techniques reported so far in the literatureforthe analysis of rosiglitazone. They include various techniques likevoltammetry, spectrophotometry, high performance liquid chromatography, high performance thin layer chromatography, liquid chromatography-electrospray ionization-tandem mass spectrometry, capillary electrophoresis-electrospray ionization-mass spectrometry for their routine, impurity profiling and stability indicating determination in different pharmaceutical dosage forms.

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Keywords

Rosiglitazone, Peroxisome proliferator-activated receptor-γ, Stability indicating methods, high performance liquid chromatography, high performance thin layer chromatography, liquid chromatographyelectrospray ionization-tandem mass spectrometry.

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