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Asian Journal of Pharmaceutical Analysis
Year : 2019, Volume : 9, Issue : 3
First page : ( 128) Last page : ( 132)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2019.00024.3

Development and Validation of Stability Indicating UV Spectrophotometric Method for Estimation of Teneligliptine in Bulk and Tablet Dosage Form

Pathade Parag A.*, Bairagi Vinod A., Ahire Yogesh S., Aher Bhaskar O.

Department of Pharmaceutical Analysis, K.B.H.S.S. Trust's Institute of Pharmacy, Malegaon-423105 Dist-Nashik (M.S.) India

*Corresponding Author E-mail: paragapathade@gmail.com

Online published on 31 December, 2019.

Abstract

A simple, sensitive, accurate, precise, reproducible and cost effective stability indicating UV spectrophotometric method has been established for quantitative determination of Teneligliptine in bulk and pharmaceutical formulation. The UV spectrum was scanned between 200 to 400 nm and 243 nm was choosing as maximum wavelength for absorption. Beer's law has been followed for the drug in the concentration range of 05–25μg/ml. Accuracy was found as (100.10–100.20%), precision as (%RSD 0.995–0.991) however the method was effectively functional to the pharmaceutical dosage form comprising the teneligliptine deprived of any interference through the excipients. According to ICH guidelines these outcomes from analysis has been validated. Forced degradation studies comprises the influence of temperature, oxidation, neutral, photolysis and susceptibility to hydrolysis through a extensive range of pH values, were accepted out approving to the ICH necessities which can be used for the routine and quality control analysis of Teneligliptine bulk as well in pharmaceutical formulations.

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Keywords

Teneligliptine, stability indicating, forced degradation.

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