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Asian Journal of Pharmaceutical Analysis
Year : 2018, Volume : 8, Issue : 3
First page : ( 140) Last page : ( 146)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2018.00026.1

Decisive Brunt of Physical and Chemical Exploration on Pharmaceutical Sterile Containers

Bagade Om*, Sable Mangal, Dhamale Madhuri, Tathe Reshma

PES's Modern College of Pharmacy (For Ladies), Moshi, Pune-412105

*Corresponding Author E-mail: ombagadescop@gmail.com

Online published on 24 October, 2018.

Abstract

Introduction

Packaging of pharmaceutical formulation is one of the key important point consider during the manufacturing of such sterile product. Plastic container should not interact with physicochemical properties of formulation thus its evaluation parameters are crucial. While selecting appropriate container for formulation dimension, size, solubility, elemental analysis must be check. Unless it will be difficult task to opt for evaluation of an appropriate container.

Objective

The main objective of the present study was to investigate the physicochemical parameters and to ascertain the quality attributes within the best packaging materials for sterile plastic containers.

Results

Depending upon the different findings the result was furnished as mentioned. Average dimension of infusion bottle containing total height of bottle (body with cap), total height of body (body without cap), total height of cap was determined as 196.66mm (S.D. ± 0.58), 195mm (S.D. ±1), 30mm (S.D. ± 1) respectively. Average dimension of ophthalmic bottle containing total height of bottle (body with cap), total height of body (body without cap), total height of cap was determined 73mm (S.D. ±1), 67mm (S.D. ±1), 23.33mm (S.D. ±0.577) respectively. Average overflow volume for infusion and ophthalmic bottle was found to be 549.33ml (S.D. ± 1.53) and 16ml (S.D. ±1) respectively. Elemental analysis for Halogen, Nitrogen, Sulphur was absent in both the containers. Insolubility was observed in solvents like toluene, ethyl acetate, carbon tetrachloride, 1, 4-dioxane etc.

Conclusion

Thus, Pharmaceutical packaging should look into concerned issues like child safety, correct dosage, patient traceability, tampering and diversion of pharmaceutical products.

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Keywords

Packaging, Height, Thickness, Dimensions, Solubility.

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