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Asian Journal of Pharmaceutical Analysis
Year : 2018, Volume : 8, Issue : 1
First page : ( 53) Last page : ( 57)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2018.00010.8

Development and Validation of Q-Absorbance UV Spectrophotometric Method for Simultaneous estimation of Amlodipine Besylate and Candesartan Cilexetil In bulk drugs

Prof. Patil Sushil D.*, Badhan Rohit B., Dr. Kshirsagar Sanjay J.

MET's Institute of Pharmacy, MET League of Colleges, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra, State, 422003, India

*Corresponding Author E-mail: sushilpharma@rediffmail.com

Online published on 2 June, 2018.

Abstract

A new, simple, accurate and sensitive UV-spectrophotometric absorption correction method has been developed for simultaneous determination of Candesartan Cilexetil and Amlodipine Besylate in bulk utilizing concept of standard addition. The method is based upon determination of Amlodipine Besylate at 237 nm & Candesartan Cilexetil at 254 nm methanol as a solvent. Overlay spectra of both drugs shows absorbance at 244 nm. Linearity was observed in range of 10–60 μg/ml and 2–10 μg/ml for Candesartan Cilexetil and Amlodipin Besylate respectively. The correlation coefficient value was found to near to 1. All methods were statistically validated as per ICH guidelines.

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Keywords

Candesartan Cilexetil, Amlodipine Besylate, UV-spectrophotometric, Simultaneous estimation, Method Development and Validation, ICH Guideline.

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