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Asian Journal of Pharmaceutical Analysis
Year : 2018, Volume : 8, Issue : 1
First page : ( 45) Last page : ( 48)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2018.00008.X

Application of Area Under Curve Technique for UV-Spectrophotometric Determination of Luliconazole in Bulk and Pharmaceutical Formulation

Chaudhari Mansi J.1, Chaudhari Suraj R.2, Chalikwar Shailesh S.3, Shirkhedkar Atul A.4,*

1M. Pharm. Student, Department of Quality Assurance, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule (MS) 424 405

2Assistant Professor, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule (MS) 424 405

3Professor and Head, Department of Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule (MS) 425 405

4Vice-Principal and Head, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule (MS) 425 405

*Corresponding Author E-mail: shirkhedkar@gmail.com

Online published on 2 June, 2018.

Abstract

A simple, rapid, accurate and economical UV-spectrophometric method has been developed for estimation of Luliconazole in bulk and formulation using area under curve (AUC) technique. The method applied was an area under curve (AUC) in which area under curve was integrated in the wavelength range of 279–305 nm. The λ max of Luliconazole in methanol was found to be 295 nm. The drug follows linear in the concentration range 318 μg/mL with correlation coefficient value 0.997. The proposed method was applied for qualitative and quantitative estimation of Luliconazole in pharmaceutical formulation and results were found in good agreement with the label claimed. This developed method can be used for routine analysis of Luliconazole in bulk and formulation.

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Keywords

Luliconazole, UV-Spectrophotometry, Area under Curve, Validation, ICH guideline.

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