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Asian Journal of Pharmaceutical Analysis
Year : 2018, Volume : 8, Issue : 1
First page : ( 33) Last page : ( 38)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2018.00006.6

Development and Validation of Absorption Correction Method for Simultaneous Estimation of Paracetamol and Nimesulide in Bulk and Combined Tablet Dosage Form

Waichal Dnyaneshwari D.*, Tambe Vrushali S.

Dept. of Quality Assurance Technique, PES's Modern College of Pharmacy (For Ladies), Moshi, Pune-412 105, Maharashtra, India

*Corresponding Author E-mail: dkmbsp@gmail.com

Online published on 2 June, 2018.

Abstract

The present paper describes simple, accurate, rapid, precise and sensitive UV spectrophotometric absorption correction method for the simultaneous determination of paracetamol and nimesulide in combined tablet dosage form. This method is more simple than reported methods and is based on use of 0.1 N NaOH as a solvent. The wavelengths selected for the analysis were 257 nm and 393 nm. Beer's law was obeyed in the concentration range of 4–18 μg/ml and 10–30 μg/ml for paracetamol and nimesulide respectively. The mean percentage drug content for paracetamol and nimesilide were found to be 100.03% w/w and 101% w/w respectively. The % RSD value was found to be less than 2 which shows the precision of method. The high recovery and low coefficients of variation conforms it's suitability for the routine quality control analysis of paracetamol and nimesulide in pure and tablet dosage forms.

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Keywords

Paracetamol, Nimesulide, Spectrophotometric absorption correction method.

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