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Asian Journal of Pharmaceutical Analysis
Year : 2018, Volume : 8, Issue : 1
First page : ( 25) Last page : ( 32)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2018.00005.4

Development and Validation of UV Spectrophotometry and RP-HPLC Method for simultaneous determination of Rosuvastin and Clopidogrel in Tablet Dosage Form

Telrandhe Roshan*

Kamla Nehru College of Pharmacy, Butibori, Nagpur, 441108, Maharashtra, India

*Corresponding Author E-mail:

Online published on 2 June, 2018.

Abstract

The aimed of research the method development and validation by UV spectrophotometry and RP HPLC method of the Rosuvastatin calcium and Clopidogrel bisulphate. The method is a simple, accurate, specific, precise, reproducible and sensitive. The λ max of ROSU and CLOP was found to be 240nm. The coefficient correlation 0.999, the Beer's Law limit 50–150 μg/ml, from the four trial of different concentration of mobile phase was selected Methanol: Water 80: 20 v/v, pH 3.0 at 240nm, flow rate 1ml/min, sample inlet 20 μL, C 18 Prontosil, %RSD of ROSU 1.017 and CLOP 0.173, theoretical plates ROSU 7797.53 and ROSU 8257.53, Retention time of ROSU 3.483min and CLOP 4.983min, Tailing factor ROSU 1.1787 and CLOP 1.074, limits 2 NMT, Accuracy ROSU 0.37% RSD, Recovery 99.59% and CLOP 0.18%RSD, recovery 100.41% was show good efficacy and results. The methods indicate future scope in analysis quality control of the estimation of ROSU and CLOP for routine drug quality analysis investigation.

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Keywords

UV Spectrophotometry, RP HPLC, Rosuvastatin calcium, Clopidogrel bisulphate, Simultanious estimation, validation.

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