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Asian Journal of Pharmaceutical Analysis
Year : 2017, Volume : 7, Issue : 4
First page : ( 218) Last page : ( 224)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2017.00035.7

Comparison Study of Conventional and Microwave Assisted Force Degradation by RP-HPLC Method of Pharmaceutical Drug and Dosage form

Patil Sushil D.1,*, Varpe Prajkta2, Chaure Sayali2, Kshirsagar Sanjay2

1Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra, India

2MET's Institute of Pharmacy, MET League of Colleges, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra, State, 422003, India

*Corresponding Author E-mail: sushilpharma@rediffmail.com

Online published on 2 June, 2018.

Abstract

Comparison Study of conventional and Microwave assisted Force Degradation by using RP-HPLC was carried for determination of Piracetam in film coated tablets. A Grace C18 (250mm x 4.6ID, Particle size: 5 micron)RP18 column with a mobile phase consisting of Methanol: Water(20: 80v/v) was used. Microwave assisted Force Degradation was performed acid, alkali, wet heat, oxidative and dry heat degradation study to prove that similar degradation product using microwave oven reduced time as compared to conventional. Quantitative evaluation was performed at 205 nm. The HPLC method is selective, precise and accurate and can be used for routine analysis of preparations in pharmaceutical industry quality control laboratories.

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Keywords

RP-HPLC, Force degradation, microwave and Piracetam.

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