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Asian Journal of Pharmaceutical Analysis
Year : 2017, Volume : 7, Issue : 4
First page : ( 203) Last page : ( 208)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2017.00032.1

Validated Simultaneous UV Spectrophotometric Methods for estimation of Tramadol Hydrochloride and ketorolac Tromethamine in bulk and marketed Capsule Formulation

Tambe V. S.1,4,*, Deodhar M. N.2,4, Prakya Vijayalakshmi3,4

1PES Modern College of Pharmacy for Ladies, Pune

2S.G.R.S. College of Pharmacy, Pune

3Siddhartha Institute of Pharmacy

4J.N.T. University, Hyderabad

*Corresponding Author E-mail: vrushali.tambe@rediffmail.com

Online published on 2 June, 2018.

Abstract

The present study describes new, simple, rapid and novel spectrophotometric methods for simultaneous estimation of Tramadol Hydrochloride and Ketorolac Tromethamine combination was analysed by simultaneous equation method (Method B) and First order derivative spectroscopic method (Method C). Method A involved measurement of absorbance at two wavelengths, 271 nm and 246 nm, λmax of tromethamine respectively. For method B, wavelengths 331 nm (for determination of Ketorolac tromethamine) and 271 nm were used. For method C, wavelengths 339.2 nm (Zero crossing of Tramadol hydrochloride) and 229.4 nm (Zero crossing of Ketorolac tromethamine) were used for determination of Ketorolac tromethamine and Tramadol hydrochloride respectively. Beer's law was obeyed in concentration range of 5–50 μg/ml and 2–20 μg/ml for Tramadol hydrochloride and Ketorolac tromethamine respectively by all the methods. Method C was found to be more simple and sensitive. The proposed methods are pharmaceutical formulations due to their specificity, rapidity, simplicity and accuracy. These methods validated for linearity, accuracy and precision as per ICH guidelines.

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Keywords

Tramadol Hydrochloride, Ketorolac Tromethamine, UV Spectroscopy.

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