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Asian Journal of Pharmaceutical Analysis
Year : 2017, Volume : 7, Issue : 3
First page : ( 196) Last page : ( 200)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2017.00031.X

Stability Indicating High Performance Liquid Chromatographic Assay for the Determination of Sildenafil Tartrate

Chandana O.S.S.1, Babu R. Ravichandra1

1Department of Chemistry, Institute of science, GITAM University, Visakhapatnam, Andhra Pradesh, India

*Corresponding Author E-mail: osschandana@gmail.com

Online published on 17 October, 2017.


A simple, fast, accurate and specific reverse phase high pressure liquid chromatographic (HPLC) method has been developed for simultaneous determination of Sildenafil base and its impurities in the Sildenafil Tartrate (API). The method was developed by reversed phase chromatography equipped with C18 (100 × 4.6 nm × 5.0 nm) column using mobile phase of (0.1%) formic acid and methanol (30: 70 ratio) with a flow rate of 0.5 ml/min with ultraviolet detector configured at 290nm. The method was validated as per ICH guidelines.



sildenafil tartrate, HPLC, Stability indicating, method development, validation.


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