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Asian Journal of Pharmaceutical Analysis
Year : 2017, Volume : 7, Issue : 1
First page : ( 15) Last page : ( 17)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2017.00003.5

Development and Validation of Visible Method for Estimation of Cilazapril in Bulk Formulation by MBTH Reagent

Dagar Chavi, Reddy G. Rohit*, Prasad VVS. Rajendra

Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India

*Corresponding Author E-mail: rohitreddy1610@gmail.com

Online published on 18 September, 2017.

Abstract

A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Cilazapril in Bulk form. The method is based on the reaction of Cilazapril with MBTH Reagent [3-Methyl-2-Benzothiazolinone Hydrazone] in the presence of Ferric chloride producing greenish yellow colour chromogen which shows maximum absorbance at 402nm against reagent blank. The Chromogen obeyed Beer's law in the concentration range of 10–50 μg/ml for Cilazapril. The results of the analysis have been validated statistically and recovery studies.

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Keywords

Cilazapril, MBTH Reagent, Ferric chloride, Visible Spectrophotometric.

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