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Asian Journal of Pharmaceutical Analysis
Year : 2016, Volume : 6, Issue : 2
First page : ( 119) Last page : ( 121)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2016.00018.1

UV Spectrophotometric Method for Estimation of Eprosartan Mesylate in Bulk and in Pharmaceutical Formulation

Bhupendra Pandya Dimple1,*, Manohar Shinkar Dattatraya2, Bhanudas Saudagar Ravindra1, Kailas Bacchav Jyoti3

1Department of Pharmaceutics, KCT's R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra

2Department of Quality Assurance Techniques, KCT's R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra

3Department of Pharmaceutical Chemistry, KCT's R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra

*Corresponding Author E-mail: dimplepandya6293@gmail.com

Online published on 21 July, 2016.

Abstract

UV Spectrophotometric method provides a simple, efficient, precise and accurate method for development and validation of Eprosartan mesylate in bulk and its tablet formulation. The present study is based on measurement of the absorbance of Eprosartan mesylate solution in methanol: phosphate buffer pH 7.4 (10:90) at 293 nm in wavelength length of 200-400nm. Beers law was observed in the range of 5–25 ppm for this method. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification which proves the suitability of this method for estimation of EPM in bulk and its tablet formulation. Results of recovery studies shows that the method was not affected by the presence of common excipients in tablets. Thus the method was found to be simple, economical, accurate and reproducible.

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Keywords

Eprosartan mesylate, UV Spectrophotometry, phosphate buffer ph7.4.

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