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Asian Journal of Pharmaceutical Analysis
Year : 2016, Volume : 6, Issue : 2
First page : ( 109) Last page : ( 114)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2016.00016.8

Simultaneous Estimation of Atenolol and Ivabradine HCl using UV-Spectrophotometry

Patil Pooja A.1,*, Dr. Raj Hasumati A.1, Dr. Sonara Gautam B.2

1Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat, India

2Department of Quality Assurance, Gujarat Technological University, Vishvkarma Road, Chandkheda, ONGC Circle, Ahmadabad, India, 394110

*Corresponding Author E-mail: patilpooja1611@gmail.com

Online published on 21 July, 2016.

Abstract

A simple, accurate, precise, economic, robust and rugged UV spectrophotometric method has been developed for the simultaneous estimation of Atenolol and Ivabradine HCl in synthetic mixture. Combination of Atenolol and Ivabradine HCl has not any analytical method developed yet, so this UV method is novel for combined synthetic dosage of Atenolol and Ivabradine HCl (10:1). The absorbance maxima of Atenolol and Ivabradine HCl were found to be 276.00 nm and 286.50 nm respectively. Beer law obeyed the concentration range of 20–100 μg/ml and 2–10 μg/ml for Ivabradine HCl. The result of analysis was validated statistically and by the recovery studies. The %RSD value of all validation parameter less than 2. The proposed method can be effectively applied for the estimation of these two drugs.

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Keywords

UV spectrophotometry, Atenolol, Ivabradine HCl, Simultaneous method.

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