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Asian Journal of Pharmaceutical Analysis
Year : 2016, Volume : 6, Issue : 1
First page : ( 41) Last page : ( 46)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2016.00007.7

Development and Validation of Analytical Method for Aripiprazole and Escitalopram Oxalate by Simultaneous Equation Spectroscopic Method

Solanki Divya1,2,*, Raj Hasumati2, Prajapati Neelam2

1Research Scholar 2014, Gujarat Technological University, Gujarat

2Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat

*Corresponding Author E-mail: divyasolanki844@gmail.com

Online published on 2 April, 2016.


A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Aripiprazole and Escitalopram Oxalate in synthetic mixture using simultaneous equation Method. In this spectroscopic method, 255.00 nm and 238.00 nm wavelengths were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 5–30 μg/ml and 15–75 μg/ml at their respective λmax. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.129 and 0.223μg/ml Aripiprazole and Escitalopram Oxalate, respectively. The limit of quantification was 0.392 and 0.677 for Aripiprazole and Escitalopram Oxalate, respectively. Recovery of Aripiprazole and Escitalopram Oxalate in were found to be 100.66% and 100.70% respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.



Aripiprazole, Escitalopram Oxalate, simultaneous estimation, Simultaneous equation method, analysis method.


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