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Asian Journal of Pharmaceutical Analysis
Year : 2015, Volume : 5, Issue : 4
First page : ( 214) Last page : ( 218)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2015.00034.4

Ranolazine: A Review on Analytical Method and Its Determination in Synthetic Mixture

Patel Vishakha D., Hasumati Raj*

Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat

*Corresponding Author E-mail: ruchajigar6114@gmail.com

Online published on 29 January, 2016.

Abstract

Ranolazine is a piperazine derivative is a new anti-ischemic drug for the treatment of angina. Ranolazine is to inhibit late INa thus preventing sodium overload of the cell. As a consequence, ranolazine prevents reverse mode sodium-calcium exchange and thus diastolic accumulation of calcium possibly resulting in improved diastolic tone and improved coronary blood flow. This review article represents the various analytical methods which has been reported for estimation of Ranolazine in synthetic mixture. The spectrophotometric techniques like fluorescent assay and area under curve spectroscopy; Chromatographic methods like HPLC, HPTLC and RP HPLC, GC, LC-MS, LC-MS/MS were reported.

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Keywords

Olmesartan medoxomil, Forced degradation studies, Degradation products, LC, LCMS, NMR, IR and TLC.

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