(3.235.41.241)
Users online: 1728    [ij] [ij] [ij] 
Email id
 

Asian Journal of Pharmaceutical Analysis
Year : 2015, Volume : 5, Issue : 4
First page : ( 209) Last page : ( 213)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2015.00033.2

Analytical UV Spectroscopic Method Development and Validation for the Estimation of Mycophenolate Mofetil

Pattanayak Suman, Prasanna A. Alekhya, Kiranmayi Ch., Padmalatha K.

Department of Pharmaceutical Analysis and Quality Assurance, Vijaya Institute of Pharmaceutical Sciences for Womenn. NH-5, Enikepadu, Vijayawada-521 108

*Corresponding Author E-mail:

Online published on 29 January, 2016.

Abstract

A simple, precise, accurate UV-spectroscopic method was developed and validated for the determination of Mycophenolate Mofetil in bulk and dosage form using solvents like methanol for dissolving the drug and acetate buffer of pH-3.5 for dilutions. At the λmaxof 250nm, it was proved linear in the range 10–50 μg/ml, and exhibit good correlation coefficient (R2 =0.995) and excellent mean recovery (99.990–100.014). The developed method was validated for accuracy, precision, robustness, ruggedness according to ICH guidelines. All these parameters showed adaptability of the method for the quality control analysis of Mycophenolate Mofetil in bulk and in marketed formulation.

Top

Keywords

Mycophenolate Mofetil, UV-Spectroscopy, Acetate buffer, Validation.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
486,235,207 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.