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Asian Journal of Pharmaceutical Analysis
Year : 2015, Volume : 5, Issue : 1
First page : ( 41) Last page : ( 45)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2015.00008.3

Isoniazid: A Review of Analytical Methods

Madhavi R.*, Krishna A. Mohana, Rani G. Shobha, Mounika D.

Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Rangampet, Tirupati-517501, Chittoor Dist, Andhra Pradesh, India

*Corresponding Author E-mail: madhavikumarpharma@gmail.com

Online published on 2 May, 2015.

Abstract

Isoniazid is an anti –tubercular drug, which is mostly used in the treatment and prevention of tuberculosis. It acts by inhibiting the synthesis of mycolic acid, required for mycobacterial cell wall synthesis in mycobacterium(M) tuberculosis. This article examines published analytical techniques that are reported so far for the determination of isoniazid in bulk, pharmaceutical formulation and biological samples. They include various techniques like spectrophotometry, electrochemical methods, capillary electrophoresis, high performance liquid chromatography, high performance thin layer chromatography, capillary gas chromatography and liquid chromatography-mass spectrophotometry.

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Keywords

Isoniazid, Analytical methods, Tuberculosis, Mycolic acid.

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