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Asian Journal of Pharmaceutical Analysis
Year : 2020, Volume : 10, Issue : 4
First page : ( 189) Last page : ( 194)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2020.00035.6

UV spectrophotometric estimation of propranolol hydrochloride and rosuvastatin calcium in synthetic mixture using first order derivative method

Dr. Patel Ajay I., Gosai Shweta V.*, Dr. Vyas Amikumar J., Dr. Patel Nilesh K., Dr. Patel Ashok B.

Pharmaceutical Quality Assurance Department, B. K. Mody Government Pharmacy College, Rajkot, Gujarat, India

*Corresponding Author E-mail: shwetagosai97@gmail.com

Online published on 27 April, 2021.

Abstract

To develop sensitive, accurate, precise and understandable UV spectrophotometric method for estimation of Propranolol hydrochloride and Rosuvastatin calcium in synthetic mixture. First order derivative simultaneous estimation was carried out by using UV visible double beam spectrophotometer. Propranolol hydrochloride and rosuvastatin calcium exhibited absorbance at working wavelength 239.43nm and 249.03nm respectively using distilled water as a solvent. Linearity was found in range of 1-24μg/ml for propranolol hydrochloride and rosuvastatin calcium. Accuracy was obtained between 95.40-103.40% that is 101.50% for Propranolol hydrochloride and 100.16% for Rosuvastatin calcium. Method was validated for its linearity, accuracy, precision, LOD, LOQ and robustness as per ICH guidelines. The aforementioned method was found specified for estimation of synthetic mixture without interference.

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Keywords

Propranolol hydrochloride, Rosuvastatin calcium, First order derivative, UV spectrophotometric, ICH.

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