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Asian Journal of Pharmaceutical Analysis
Year : 2020, Volume : 10, Issue : 4
First page : ( 185) Last page : ( 188)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2020.00034.4

Spectrophotometric method for the estimation of cetirizine hydrochloride in pharmaceutical preparation

Urs Raj S. Subramanya*, Bindu M., Ramyashree D., Sowmya K. N.

Post Graduate Department of Chemistry, JSS College for Women, Sarawathipuram, Mysuru, 570 009

*Corresponding Author E-mail: ssrajurs@yahoo.co.in

Online published on 27 April, 2021.

Abstract

Present study describes development and validation of UV- Spectrophotometric method for the estimation of Cetirizine Hydrochloride in pharmaceutical preparation. In the proposed methods methanol, water and 0.1N NaOH solution is employed. Absorption maxima was determined with 10μg/ml solution by scanning in the range 200-400nm. Standard and stock solution was prepared in methanol, (λmax :238nm), water and 0.1N NaOH (λmax: 230nm). The proposed methods obey Beer’s law in the range 2-60μg/ml. The methods ware validated in terms of linearity, precision and accuracy. Results of analysis were validated statistically and by recovery studies. It was observed that there is no interference of impurities or excipients during the estimation of drug. This shows the adoptability of the methods for the routine quantitative analysis of drug in marketed formulations and conduction of analysis at less cost compared to other instrumental methods.

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Keywords

Antihistamine, Seasonal allergic rhinitis, Chromatographic methods.

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