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Asian Journal of Pharmaceutical Analysis
Year : 2020, Volume : 10, Issue : 3
First page : ( 147) Last page : ( 149)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2020.00026.5

UV spectrophotometric method development and validation of acotiamide in bulk and solid doage form

Matole Vinod*, Birajdar Avinash, Ingle Suyash, Adlinge Sagar, Nangare Gajanand, Madur Saili, Patil Smeeta, Shegaonkar Anita

D.S.T.S Mandal's College of Pharmacy, Solapur-413004, Maharashtra, India

*Corresponding Author E-mail: matole7414@gmail.com

Online published on 16 September, 2020.

Abstract

Objective: A new, simple, sensitive, precise and reproducible UV spectroscopic method was developed for the estimation of Acotiamide in bulk and Tablet Formulation. Methods: The UV spectrum of Acotiamide in water showed λ max at 249 nm. Beer's law is valid in the concentration range of 3–18μg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness. Results: The method has demonstrated excellent linearity over the range of 3–18μg/ml with regression equation y = 0.0523x - 0.0429 and regression correlation coefficient r2= 0.9996. Moreover, the method was found to be highly sensitive with LOD (0.38μg/ml) and LOQ (1.17μg/ml). Conclusion: Depending on results the given method can be successfully applied for assay of Acotiamide in Tablet formulation.

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Keywords

Acotiamide, UV spectroscopy, Method development and validation, Water Tablet Formulation.

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