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Asian Journal of Pharmaceutical Analysis
Year : 2020, Volume : 10, Issue : 2
First page : ( 77) Last page : ( 80)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2020.00013.7

Spectrophotometric method for the estimation of Atorvastatin calcium in pharmaceutical preparation

Urs S. Subramanya Raj*, Gangambika H.M., Murthy M. Rajashekara, Asharani D.R.

Post Graduate Department of Chemistry, JSS College for Women, Sarawathipuram, Mysuru, 570 009

*Corresponding Author E-mail: ssrajurs@yahoo.co.in

Online published on 3 June, 2020.

Abstract

Present study describes development and validation of UV-Spectrophotometric method for the estimation of Atorvastatin Calcium in pharmaceutical preparation. During development of analytical methods, methanol and hydrotropic solubilization reagent is employed to enhance aqueous solubility of poorly water soluble Atovastatin Calcium in dosage forms. In the proposed methods 2M Urea and 2M Thiourea solution is used as hydrotropic solubilizing agent. Absorption maxima was determined with 10μg/ml solution by scanning in the range 200-400nm. Standard stock solution prepared in methanol (λmax: 247nm) and hydrotropic solubilization agent in water(λmax: 240nm). The proposed methods obeys Beer's law in the range 5–40 μg/ml. The methods were validated in terms of Linearity, Precision and Accuracy. Results of analysis were validated statistically and by recovery studies. It was observed that there is no interference of impurities or excipients during the estimation of drug. This shows the adoptability of the methods for routine analysis of drugs in marketed formulations in quality control laboratories.

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Keywords

Hydrotropic solubilization agent, Absorption maxima, Standard stock solution.

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