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Annals and Essences of Dentistry
Year : 2011, Volume : 3, Issue : 3
First page : ( 1) Last page : ( 6)
Print ISSN : 0975-8798. Online ISSN : 0976-156X.

Histological and histometric analysis of solitary and non-syndrome associated multiple odontogenic keratocysts.

K Paremala1,*Reader, B Radhika M1Professor and Head, Thambiah Lalita J1Professor, Solomon Monica C.2Professor, Rao Nirmala N2Professor, Kaur Gurkiran3Reader

1Department of OralPathology, Krishnadevaraya College of Dental Sciences, Bangalore

2Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal

3Department of Oral Pathology, Gian Sagar Dental College and Hospital, Patiala, Punjab

*Corresponding Author: Dr.Paremala. K, Reader Department of Oral Pathology, Krishnadevaraya College of Dental Sciences, Bangalore. Mobile:+ 919844244822, Email:paremala@gmail.com

Online published on 22 September, 2011.



Odontogenic keratocysts are common, locally destructive lesions of the head and neck region. They can occur as solitary or multiple lesions, and if multiple, they are mostly associated with Gorlin-Goltz syndrome. This study aims to categorize the OKCs which behave more aggressively, using conventional histopathological techniques.


The present study exploits conventional histopathological techniques to gain an insight into the behavior of the OKC (both solitary and non-syndrome associated multiple OKCs). The histological features (keratinization pattern, presence of satellite cysts/odontogenic islands, epithelial infoldings and corrugations) and histometric parameters (total number of nuclei, epithelial height, total nuclear density, number of basal nuclei, basement membrane length, basal nuclear density and mitotic index) were compared between the two groups of cysts.


Multiple OKCs exhibited increase in number of infoldings, corrugations, mitotic index, reduced epithelial height, total number of nuclei, number of basal nuclei, and basal nuclear density. This information may be used to predict their biologic behavior and thus serve as a basis for diagnostic and therapeutic strategies.


Conventional histopathological techniques can provide valuable information which may be useful to categorize those OKCs that have more aggressive biological behavior and helps in deciding the treatment protocol.



Odontogenic keratocyst, biologic behavior, recurrence, histometric analysis, mitoticactivity.


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