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ACADEMICIA: An International Multidisciplinary Research Journal
Year : 2020, Volume : 10, Issue : 11
First page : ( 1871) Last page : ( 1883)
Online ISSN : 2249-7137.
Article DOI : 10.5958/2249-7137.2020.01558.X

Analysis of risk factors of breast cancer development

Ergashevna Atakhanova Nigora, Muradoa Almuradova Dilbar*, Golibovna Shukrulloeva Nargiza, Shuhratovna Ismoilova Gulhayo, Mirzagiyasovna Tuychiyeva Madina

Tashkent Medical Academy, Tashkent, Uzbekistan

*Email id: dilbardoc@mail.ru

Abstract

More than 1.1 million cases of morbidity and more than 410,000 breast cancer deaths (BC) are diagnosed worldwide every year. The systematic review and analysis of the study of the influence of possible risk factors and causes of this type of cancer by the statistical materials of the oncologydatabases are essential. The study of risk factors for the incidence of breast cancer was carried out on a global scale, considering geographical and temporal variations in different regions of the world.The article analyzes the literature data on the role of the main risk factors in the mechanisms of development of breast cancer (BC) (hereditary factor, background precancerous diseases, the role of immunodeficiency, hormonal imbalance in various endocrinopathies, age factor and a number of others) on the molecular cell, organ and systemic levels. The authors focus on the mechanisms of oncogenic transformation of cells under the influence of hyperestrogenism of various origins, against the background of hypothyroidism, as well as excessive formation of free radicals in various forms of pathology that have mutagenic activity and disrupt the processes of intercellular interaction. An important role in the transition of the first stage of carcinogenesis -oncogenic transformation to the stage of promotion is assigned to the previous and concomitant immunodeficiency states, when the elimination of malignant cells is impaired.

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Keywords

Morbidity, Mortality, Causes, Risks, Breast Cancer.

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