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ACADEMICIA: An International Multidisciplinary Research Journal
Year : 2020, Volume : 10, Issue : 11
First page : ( 1510) Last page : ( 1516)
Online ISSN : 2249-7137.
Article DOI : 10.5958/2249-7137.2020.01467.6

The state of the prostacycline-thromboxane system in patients after aortic coronary bypassing

Khattahanova Rabiya Yuldashevna

Head of the Department of Propedeutics of Internal Diseases, Candidate of Medical Sciences, Fergana Branch of The Tashkent Medical Academy, Uzbekistan, Email id: rabiya.khattahanova@mail.ru

Abstract

In order to clarify the role of the prostacyclin-thromboxane system (PTS) in the development of acute circulatory disorders in the early postoperative period after coronary artery bypass grafting, its condition was studied in 56 patients with coronary artery disease. In patients with the development of vascular insufficiency and shock, a decrease in the level of thromboxane in the blood was revealed, while in patients with arterial hypertension, increased concentrations of thromboxane in the blood were determined in the absence of changes in the level of prostacyclin. There were no significant differences in the content of prostacyclin and thromboxane between the groups of patients with an uncomplicated course of the postoperative period and with the development of complications such as heart failure and hypovolemia. It was found that the factors influencing the state of PTS in patients after CABG surgery are: the duration of artificial circulation, blood loss during surgery, the number of platelets in the blood, hypocapnia. The factors influencing the platelet aggregation ability are: the duration of artificial circulation, the number of platelets, the degree of "emptying" of the alpha granules of platelets, the functional state of the PTS.

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Keywords

Prostacyclin-Thromboxane System, Hemostasis, Platelet Aggregation, Heart Failure, Coronary Artery Bypass Grafting.

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